Few years ago I had suffered severe depression due to the occurrence of certain personal events in my life. The result was I had no concentration or interest in anything that I did.  My social life had also become zero and gradually it stated taking a toll on my overall health. Then a friend of mine recommended me to try Doctors Best SAMe 400mg tablets. Since I have stated consuming these I can say that my life is back on track again. These have been instrumental in restabilizing my mood and getting my confidence back. I would definitely recommend the product to anybody looking to enhance their cognitive health and overall well being.

Introduction to “Doctors Best SAMe 400″

Doctors Best SAMe 400 has been proven to be an effective mood enhancer and a good aid in promoting cognitive health in many. I can say that these are a blessing in disguise for people like me suffering minor anxiety and depression or mood swings.  They work by promoting a healthy metabolism of the brains transmitters.

Introduction to Doctors Best SAMe 400

What is “Doctors Best SAMe 400”?

SAMe-400 or better known as S-adenosylmethionine is made from the amino acid methionine and ATP. Off late this has been used as a dietary supplement that is effective in improving brain functions and cognitive health. These are mainly available in the form of tablets and can be consumed orally. The available standard dosage is 400mg tablets that are known to contain 400mg of active SAMe in them. This is the active ingredient in the tablets and apart from this there are other ingredients as well in the product. These include cellulose, magnesium silicate, mannitol, iron oxide, titanium dioxide, triethyl citrate etc. All the ingredients are clearly mentioned on the package and it does not contain any other hidden ingredients.

What is “Doctor’s Best”?

Double Strength SAMe 400 is manufactured by a well known brand Doctor’s Best. This is a science based nutritional supplement company that boasts of more than 200 products. The wide range of products includes vitamins, minerals, amino acids and supplements etc.  All the products are made with highest quality ingredients and are well researched and tested.

User Reviews

The product enjoys patronage across various sections of people. People have openly praised the product on various online platforms for all the benefits it provides. Many have said this product to be a blessing in disguise as it helps them fight mood swings, depression and lack of motivation. For some ladies, the product has helped deal with the pre menopause mood swings and sometimes knee pains as well. People have found this to be a very good alternative to the antidepressant pills that do more harm than good. Many users have said to be more in control of their emotions after using the product for a considerable period of time. Across various platforms, online the product has been reviewed to be a very good choice for improving once cognitive health.

User Reviews

What to Expect? 

Doctors Best SAMe 400 is a unique product that not only enhances your mood but also has the ability to enhance cartilage protection as well. For people of my age where joint problems are a common feature the product has been a great help in improving mobility and movement. These are a great source of dietary supplements that will help you fight depression, anxiety and mood swings. Other then this it will be instrumental in gaining your confidence back.

Effects and Benefits

  • The product has been proved very effective in reducing the joint pains and increasing comfort. This is due to the fact that it promotes the synthesis of proteoglycans which is an important component of the connective tissue.
  • It is clinically proven to be very effective in improving your mood and overall cognitive health. For doing so they facilitate the brain cell’s methylation thereby facilitating the youthful DNA enzymatic action.
  • It also improves body’s antioxidant defence and maintains the acetylcholine levels.
  • The product has been instrumental in maintaining good liver health.
  • A preferred choice for vegans as it is soy free and gluten free.

Suggested Dosages

One tablet a day should be an ideal dosage for consuming SAMe 400. If you wish to increase the dosage then it is advisable to consult your doctor or a nutritionally informed professional.

How to consume

Always consume it between meals or as recommended by the doctor. Many doctors recommended that this should be consumed with vitamins B12, B6 and folic acid. Other than this, refrain from crushing or chewing the tablet.

Side Effects

The product is considered to be safe whether given intravenously or in the form of capsules. But sometimes certain mild symptoms have been reported by many. These include headache, dry mouth, insomnia, dizziness and nervousness. The symptoms are rare and should subside with time but if they persist contact your doctor. Also in a very small percentage of people, the product has been reported to cause gastro intestinal discomfort.

Dangers & Safety

Normally the product is safe to use but should be avoided in certain situations like pregnancy.  This is so because there is not much information available about its safety during the early trimesters of pregnancy. Hence one should avoid it to be safe during pregnancy. People should also avoid using it during the period of breastfeeding to avoid complications for the child.

Using SAMe might worsen the symptoms of Parkinson’s disease and Lesch-Nyhan Syndrome. Hence it is advisable to avoid usage.

Also one should stop consuming the product at least 2 weeks prior to undergoing any surgery. This is so because it is likely to interfere with the central nervous system.

The product also should not be consumed by people who are suffering from bi polar disorder as it can aggravate the symptoms.

From a safety point of view always keep them out of reach from children.

Where to Buy

The product can be purchased easily at various online stores like Amazon at very affordable prices. For more information, click here.

Is SAMe 400 safe for Health?

The product is safe for consumption as there are no adverse or major side effects. But ensure that is consumed by adults above 18 years of age.



I would definitely recommend the product to others as it has proven benefited to enhance your mood and improve overall cognitive health. But I would advise consulting your doctor before taking these supplements as they have the potential to interfere with any other medication that you might be taking.